Heavy rain is possible Lower Mississippi Valley to the Ohio Valley, according to the National Weather Service (NWS).
Snow is forecast from parts of the Middle Mississippi Valley/Tennessee Valley to the Mid-Atlantic/Southern New England. Meanwhile rain/freezing rain and sleet may develop from parts of the Southern Plains to the Southern Mid-Atlantic.
Temperatures will be 15 to 35 degrees below average for the Upper Midwest to the Southern Plains/Middle Mississippi Valley. Snow will develop over parts of the Central Rockies/Central Plains will expand into the Ohio Valley/Northern Appalachians by Wednesday evening.
The snow will become moderate over parts of the Ohio Valley on Wednesday evening that will move into parts of the Northern Mid-Atlantic by Thursday morning and off the Mid-Atlantic Coast by Thursday evening.